As enterprises grapple with 53% annual growth in data-intensive workloads and 78% of IT leaders prioritize infrastructure scalability, HPE ProLiant DL360 servers remain pivotal for balancing performance, density, and efficiency. This technical guide analyzes proven configurations that transform these 1U workhorses into adaptable powerhouses for modern computing demands.
Foundation for Virtualization & Cloud
The DL360 Gen10 Plus excels in virtualized environments with its modular architecture:
- CPU: Dual 3rd Gen Intel Xeon Scalable (40 cores, 3.8GHz boost)
- Memory: 32x 64GB DDR4-3200 (2TB total) with persistent memory support
- Storage: 8x 3.84TB NVMe SSDs in RAID 60 (28TB usable)
- Networking: Dual 25G SFP28 + 10G Base-T LOM
A financial services firm achieved 98% consolidation ratio by hosting 450 VMs across 10 DL360 nodes, reducing rack space by 60% compared to previous Gen8 systems.

AI/ML Acceleration Configurations
For machine learning inference at the edge:
- GPU Support: 3x NVIDIA A30 (24GB HBM2 each) via PCIe risers
- CPU: Xeon Platinum 8368 (38 cores, 4.4GHz Turbo)
- Memory: 1.5TB DDR4 + 512GB Intel Optane PMem 300 series
- Fabric: 100G CX6 adapters with RoCE v2 optimization
Performance metrics from a manufacturing deployment:
- 42,000 inferences/hour on computer vision models
- 19ms latency for real-time defect detection
- 8.4 TFLOPS per node with FP16 precision
High-Performance Database Clusters
OLTP-optimized DL360 setup:
storage_config:
controller: HPE Smart Array E208i-p
drives:
- 6x 1.6TB SAS SSD (RAID 10)
- 2x 800GB Write-Intensive SSD (log volumes)
memory:
channels: 8x 128GB DDR4-3600
network:
teaming: 4x 10G LACP with jumbo frames
A telecom provider achieved 2.3 million transactions/second on Oracle Exadata, reducing query latency by 73% versus all-flash arrays.
Hyperconverged Infrastructure (HCI) Blueprint
For VMware vSAN or Nutanix deployments:
- Compute: 2x Xeon Gold 6330 (28 cores, 4.3GHz)
- Cache Tier: 2x 3.2TB NVMe (Read-Intensive)
- Capacity Tier: 4x 15.36TB SAS SSD
- Networking: Dual 25G Mellanox ConnectX-6 Dx
HCI performance benchmarks:
- 450,000 IOPS (4K random read)
- 18μs latency at 70% load
- 94% storage efficiency with dedupe/compression
Security-Hardened Government Config
Meeting NIST SP 800-193 requirements:
- Silicon Root of Trust: HPE iLO 5 with TPM 2.0
- Encrypted Drives: FIPS 140-2 Level 2 SEDs
- Firmware: Signed boot process with secure recovery
- Network: MACsec-256Gbps on all uplinks
Defense contractors report 99.999% compliance audit success using these hardened builds.
Cost-Optimized SMB Solution
Balancing performance and budget:
- CPU: Single Xeon Silver 4310 (12 cores, 3.4GHz)
- Memory: 8x 32GB DDR4-2933
- Storage: 4x 960GB SATA SSD (RAID 5)
- Warranty: 3-year 6-hour response
Total system cost: <$12,000 with 5-year TCO 38% lower than public cloud equivalents.
Future-Proofing Considerations
The DL360 Gen10 Plus’s modular design enables:
- Liquid Cooling Readiness: 300W TDP support per CPU
- CXL 1.1 Memory Expansion: Planned 2023 Q4
- Quantum-Safe Encryption: PCIe 5.0 slot compatibility
- 400G Network Upgrade Path: QSFP-DD adapters
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